Neuroses and psychopathies accompanied by fear, anxiety, restlessness; reactive depressive states (including those with somatic diseases), panic disorder, withdrawal syndrome in patients with alcoholism and drug addiction – all these conditions in which you can take Farmapram.
Pharmacological action – anxiolytic, myorelaxant, central, sedative.
Binding to benzodiazepine and GABAergic receptors causes inhibition of limbic system, thalamus, hypothalamus, polysynaptic spinal reflexes. After oral administration, it is rapidly absorbed from the gastrointestinal tract. Cmax is reached after 1-2 hours. Binding to plasma proteins is 80%. It passes through the HEB and the placental barrier, penetrates into breast milk. It is metabolized in the liver. T1/2 is 16 hours. It is mainly excreted by the kidneys. Repeated administration at intervals of less than 8-12 hours may lead to cumulation.
Do not take Farmapram if there is hypersensitivity, marked respiratory failure, glaucoma (acute attack), acute liver and kidney disease, myasthenia gravis, pregnancy (especially the first trimester), breast-feeding, age under 18 years. Also, open-angle glaucoma, sleep apnea, chronic renal and/or hepatic insufficiency, alcoholic liver damage.
Side effects of the substance Alprazolam
Drowsiness, fatigue, dizziness, unsteady gait, slowed mental and motor reactions, decreased concentration, nausea, constipation, dysmenorrhea, decreased libido, itching, paradoxical reactions (aggressiveness, agitation, irritability, anxiety, hallucinations), addiction, drug dependence, withdrawal syndrome.
Note that anxiety or tension associated with everyday stress usually does not require treatment with anxiolytics. If paradoxical reactions occur, it is necessary to stop taking the drug. Consumption of alcoholic beverages is inadmissible during treatment. Use with caution during work of drivers of vehicles and people whose profession is connected with high concentration of attention.
- Symptoms: CNS depression of varying severity (from somnolence to coma) – somnolence, confusion, in more severe cases (especially during use of other CNS-depressing drugs or alcohol) – ataxia, decreased reflexes, hypotension, coma.
- Treatment: induction of vomiting, gastric lavage, symptomatic therapy, monitoring of vital functions. In marked hypotension – injection of norepinephrine. Specific antidote – benzodiazepine receptor antagonist flumazenil (administration only in hospital).
Increases the effect of alcohol, neuroleptics and hypnotics, narcotic analgesics, central muscle relaxants. Increases the concentration of imipramine in the serum. There is a mutual enhancement of the effect when concomitant administration of antipsychotic (neuroleptic), antiepileptic or hypnotic drugs, as well as central muscle relaxants, narcotic analgesics, ethanol and drugs for general anesthesia. Inhibitors of microsomal oxidation of liver enzymes increase and inducers decrease plasma concentrations of alprazolam (alprazolam effectiveness may be altered). Alprazolam may increase the severity of BP reduction against the background of hypotensive drugs.
Increased respiratory depression is possible when concomitantly prescribed with clozapine. Reduces the effectiveness of levodopa in patients with parkinsonism. May increase toxicity of zidovudine.